USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: MED4_HUMAN USC-OGP 2-DE database:  MED4_HUMAN MED4_HUMAN General information about the entry View entry in simple text format Entry name MED4_HUMAN Primary accession number Q9NPJ6 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Mediator of RNA polymerase II transcription subunit 4; AltName: Full=Activator-recruited cofactor 36 kDa component; Short=ARC36; AltName: Full=Mediator complex subunit 4; AltName: Full=TRAP/SMCC/PC2 subunit p36 subunit; AltName: Full=Vitamin D3 receptor-interacting protein complex 36 kDa component; Short=DRIP36;. Gene name Name=MED4 Synonyms=ARC36, DRIP36, VDRIP ORFNames=HSPC126 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1299: pI=4.88; Mw=23684 Cross-references UniProtKB/Swiss-Prot Q9NPJ6; MED4_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name MED4_HUMAN Primary accession number Q9NPJ6 Secondary accession number(s) B4DX67 Q53GB4 Q53H68 Q5T912 Q6FHC4 Q6IA79 Q9BS95 Q9NYR5 Sequence was last modified on  October 1, 2000 (version 1) Annotations were last modified on  March 15, 2017 (version 147) Name and origin of the protein Description RecName: Full=Mediator of RNA polymerase II transcription subunit 4; AltName: Full=Activator-recruited cofactor 36 kDa component; Short=ARC36; AltName: Full=Mediator complex subunit 4; AltName: Full=TRAP/SMCC/PC2 subunit p36 subunit; AltName: Full=Vitamin D3 receptor-interacting protein complex 36 kDa component; Short=DRIP36; Gene name Name=MED4 Synonyms=ARC36, DRIP36, VDRIP ORFNames=HSPC126 Encoded on Name=MED4; Synonyms=ARC36, DRIP36, VDRIP; ORFNames=HSPC126 Keywords Acetylation; Activator; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF300618; AAG22542.1; -; mRNA EMBL AF230381; AAF37289.1; -; mRNA EMBL AF161475; AAF29090.1; -; mRNA EMBL AK001934; BAA91987.1; -; mRNA EMBL CR457276; CAG33557.1; -; mRNA EMBL CR541830; CAG46629.1; -; mRNA EMBL AK222713; BAD96433.1; -; mRNA EMBL AK301835; BAG63279.1; -; mRNA EMBL AK223017; BAD96737.1; -; mRNA EMBL AL158196; CAI17018.1; -; Genomic_DNA EMBL AL158196; CAI17020.1; -; Genomic_DNA EMBL BC005189; AAH05189.1; -; mRNA CCDS CCDS59241.1; -. [Q9NPJ6-2]; . CCDS CCDS9408.1; -. [Q9NPJ6-1]; . RefSeq NP_001257558.1; NM_001270629.1. [Q9NPJ6-2]; . RefSeq NP_054885.1; NM_014166.3. [Q9NPJ6-1]; . UniGene Hs.181112; -; . UniGene Hs.741275; -; . ProteinModelPortal Q9NPJ6; -; . SMR Q9NPJ6; -; . BioGrid 118849; 358; . IntAct Q9NPJ6; 88; . MINT MINT-1196457; -; . STRING 9606.ENSP00000258648; -; . iPTMnet Q9NPJ6; -; . PhosphoSitePlus Q9NPJ6; -; . DMDM 29840770; -; . EPD Q9NPJ6; -; . MaxQB Q9NPJ6; -; . PaxDb Q9NPJ6; -; . PeptideAtlas Q9NPJ6; -; . PRIDE Q9NPJ6; -; . DNASU 29079; -; . Ensembl ENST00000258648; ENSP00000258648; ENSG00000136146. [Q9NPJ6-1]; . Ensembl ENST00000378586; ENSP00000367849; ENSG00000136146. [Q9NPJ6-2]; . GeneID 29079; -; . KEGG hsa:29079; -; . UCSC uc001vby.3; human. [Q9NPJ6-1]; . CTD 29079; -; . DisGeNET 29079; -; . GeneCards MED4; -; . HGNC HGNC:17903; MED4; . HPA HPA006232; -; . MIM 605718; gene; . neXtProt NX_Q9NPJ6; -; . OpenTargets ENSG00000136146; -; . PharmGKB PA134877001; -; . eggNOG KOG4552; Eukaryota; . eggNOG ENOG410XQ30; LUCA; . GeneTree ENSGT00390000012063; -; . HOGENOM HOG000043883; -; . HOVERGEN HBG052450; -; . InParanoid Q9NPJ6; -; . KO K15146; -; . OMA GLEPPGH; -; . OrthoDB EOG091G0M8S; -; . PhylomeDB Q9NPJ6; -; . TreeFam TF324421; -; . Reactome R-HSA-1989781; PPARA activates gene expression; . Reactome R-HSA-212436; Generic Transcription Pathway; . Reactome R-HSA-381340; Transcriptional regulation of white adipocyte differentiation; . ChiTaRS MED4; human; . GeneWiki MED4; -; . GenomeRNAi 29079; -; . PRO PR:Q9NPJ6; -; . Proteomes UP000005640; Chromosome 13; . Bgee ENSG00000136146; -; . CleanEx HS_MED4; -; . ExpressionAtlas Q9NPJ6; baseline and differential; . Genevisible Q9NPJ6; HS; . GO GO:0070847; C:core mediator complex; IBA:GO_Central; . GO GO:0016592; C:mediator complex; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; NAS:UniProtKB; . GO GO:0004872; F:receptor activity; IDA:UniProtKB; . GO GO:0001104; F:RNA polymerase II transcription cofactor activity; IDA:UniProtKB; . GO GO:0046966; F:thyroid hormone receptor binding; IDA:UniProtKB; . GO GO:0003712; F:transcription cofactor activity; IDA:UniProtKB; . GO GO:0042809; F:vitamin D receptor binding; NAS:UniProtKB; . GO GO:0030521; P:androgen receptor signaling pathway; IDA:UniProtKB; . GO GO:0030518; P:intracellular steroid hormone receptor signaling pathway; IDA:UniProtKB; . GO GO:0045893; P:positive regulation of transcription; DNA-templated; IDA:UniProtKB GO GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB; . GO GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB; . InterPro IPR019258; Mediator_Med4; . Pfam PF10018; Med4; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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